Inombolo ye-Cas: 144701-48-4 I-Molecular Formula:C33H30N4O2

Incazelo emfushane:

Inombolo yeCas: 144701-48-4
Igama Lekhemikhali:
I-Molecular Formula:C33H30N4O2

Amagama afanayo:MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277;PRITOR;BIBR 277;misartan;BIBR 277SE

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukucaciswa Kwemikhiqizo

I-Melting Point	261-263°C
Ukuminyana	1.16 (isilinganiso esinzima)
izinga lokushisa lokugcina	Umkhathi ongenayo, Izinga lokushisa Legumbi 2-8°C
ukuncibilika	I-DMSO: >5 mg/mL ku-60 °C
umsebenzi optical	N/A
Ukubukeka	Okuqinile Okumhlophe
Ubumsulwa	≥98%

Incazelo

yethulwa e-US ukwelapha i-hypertension.Ingalungiswa ngezinyathelo eziyisishiyagalombili kuqala nge-methyl 4-amino-3-methyl benzoate;umjikelezo wokuqala nowesibili ube yindandatho ye-benzimidazole kwenzeka ezinyathelweni 4 no-6 ngokulandelana.ivimba isenzo se-angiotensin II (Ang II), i-molecule eyinhloko ye-renin-angiotensin-aldosterone (RAAS).Kungokwesithupha kwalesi sigaba se-《sartans》 esizokhangiswa ngemva kwenhlanganisela eholayo i-Losartan.Umphumela wayo ohlala isikhathi eside (uhhafu wempilo wamahora angama-24) ungaba umehluko omkhulu nabanye abaphikisi be-angiotensin II.Ngokungafani namanye ama-ejenti amaningana kulesi sigaba, umsebenzi wawo awuncikile ekuguqulweni kwe-metabolite esebenzayo, i-1-O-acylglucuronide iyi-metabolite eyinhloko etholakala kubantu. I-angiotensin II ngenkathi intula ubudlelwano be-AT2 subtypes noma amanye ama-receptors abandakanyeka kumthethonqubo wenhliziyo.Ezifundweni ezimbalwa zemitholampilo, ngethamo elilodwa ngosuku, kwaveza imiphumela ephumelelayo neqhubekayo yokwehlisa umfutho wegazi enezinga eliphansi lemiphumela emibi (ikakhulukazi ukukhwehlela okuhlobene nokwelashwa okuhambisana ne-ACE inhibitors ezigulini esezikhulile).