Inombolo ye-Orlistat Cas: 132539-06-1 I-Molecular Formula: C28H29NO

Incazelo emfushane:

Inombolo yeCas: 132539-06-1
Igama Lekhemikhali: I-Orlistat
I-Molecular Formula: C28H29NO
Amazwi afanayo: i-olanzapine, i-Zyprexa, i-Lanzek, i-Olansek, i-Symbyax (equkethe i-fluoxetine), njll.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

imininingwane yemikhiqizo

I-Melting Point	195-200°C
Ukuminyana	1.4 g/cm³
izinga lokushisa lokugcina	2-8℃
ukuncibilika	ayincibiliki emanzini, incibilika kancane ku-ethanol, incibilika kalula ku-chloroform ne-methanol
umsebenzi optical	+71.6 (c=1.0, i-ethanol)
Ukubukeka	i-crystalline powder emhlophe noma emhlophe

imikhiqizo Sebenzisa

I-Olistat iyi-inhibitor ehlala isikhathi eside, ethize ye-lipase ye-gastrointestinal engavimbela i-hydrolysis ye-triglycerides ibe ama-fatty acids angenakumuncwa kanye ne-monoacylglycerols, ivimbele ukuthi ingamuncwa, ngaleyo ndlela inciphise ukuthathwa kwekhalori nokulawula isisindo.Uma isetshenziswa njengomuthi otholakala ngaphandle kwekhawunta ukuze uzitholele ngokwakho, i-orlistat ifaneleka ekwelapheni iziguli ezikhuluphele noma ezikhuluphele (enenkomba yesisindo somzimba engu-≥ 24 kanye nesibalo esilinganiselwe sesisindo/ubude 2).

incazelo yemikhiqizo

I-Orlistat iyisidakamizwa sokulahlekelwa isisindo, esithengiswa njenge-Xenical.
I-Olistat isuselwa ku-lipstatin.I-Lipstatin iyi-pancrelipase inhibitor yemvelo esebenzayo ehlukanisiwe ne-Streptomyces toxitricini Isebenza ikakhulukazi emgudwini wamathumbu.Ingavimbela ama-enzyme adingwa yi-gastrointestinal tract ukugaya amafutha, okuhlanganisa i-pancreatic ester ne-gastric ester, futhi inciphise ukumuncwa kwe-ester yamathumbu emafutheni ukusiza ukwehlisa isisindo, kodwa kusadingeka kuhlanganiswe nokuzivocavoca nokudla ukuze ulahlekelwe isisindo.

Ukusetshenziswa kanye Nesilinganiso

Umthamo onconyiwe wama-capsules we-Olistat ama-capsules angu-0.12g athathwe nokudla noma phakathi nehora elilodwa ngemva kokudla.Uma kukhona ukudla okungazange kudliwe noma uma ukudla kungenayo amafutha, umuthi owodwa ungashiywa.Umphumela wokwelapha wokusetshenziswa kwesikhathi eside kwamaphilisi e-orlistat, okuhlanganisa nokulawulwa kwesisindo nokuthuthukiswa kwezici eziyingozi, ungagcinwa.Ukudla kwesiguli kufanele kube nokudla okunomsoco, okunekhalori ephansi kancane.Cishe u-30% wekhalori odlayo uvela emafutheni, futhi ukudla kufanele kucebile ngezithelo nemifino.