Inombolo ye-Cas: 146-56-5 I-Molecular Formula: C20H21ClN2O4
| I-Melting Point | 176-178°C |
| Ukuminyana | 1.02 g/cm³ |
| izinga lokushisa lokugcina | idabukile ekushiseni kwegumbi, elangeni eliqondile nasendaweni enomswakama |
| ukuncibilika | 50 mg/ml (Ku-ethanol);Ayincibiliki emanzini |
| umsebenzi optical | +111.6 degrees (C=1, i-methanol) |
| Ukubukeka | i-crystalline powder emhlophe noma ecishe ibe mhlophe |
| Ubumsulwa | ≥97% |
"i-dihydropyridine calcium antagonist" (i-calcium antagonist, noma i-slow channel blocker) evimbela ukunyakaza "kwe-calcium ion" kumaseli emisipha ebushelelezi emithanjeni kanye nama-myocyte enhliziyo.Idatha yokuhlola iphakamisa ukuthi kuhlotshaniswa "nezindawo ezibophayo" ze-"dihydropyridines" kanye "nama-non-dihydropyridines".Kokubili izicubu ezibushelelezi zenhliziyo nemithambo yegazi 'izinqubo ze-contractile' zincike ekungeneni 'kwama-ion e-calcium e-extracellular' kulawa maseli ngamashaneli e-ion athile.ivimbela ngokukhetha ukugeleza kwama-ion e-calcium kuwo wonke lawa mangqamuzana olwelwesi lwamaseli, okuwumshini othinta amangqamuzana emisipha abushelelezi emithanjeni ngaphezu kwamangqamuzana enhliziyo.Umphumela ongemuhle we-inotropic (Inotrope), noma ukuncipha kwe-myocardial contractility, kungatholwa ku-vitro.Kodwa-ke, imiphumela enjalo ayizange ibonakale ezilwaneni ezilawulwa ngaphakathi kwesilinganiso sokwelapha esinqunyiwe.Ukugxila kwe-serum calcium akuthintwa yi-.Ebangeni le-pH yezemvelo, iyinhlanganisela ye-ionized (pKa=8.6) ukusebenzisana kwayo nama-receptors esiteshi se-calcium kubonakala ngenani eliqhubekayo lokuhlangana kwesayithi okubopha i-receptor nokuhlukana, futhi le ndlela yezinga eliqhubekayo iholela emphumeleni wokuqala oqhubekayo.
iyi-peripheral arterial vasodilator esebenza ngqo emisipha ebushelelezi yemithambo, okuholela ekwehleni kokumelana nemithambo ye-peripheral kanye nokwehla komfutho wegazi.Indlela eqondile ekhulula ngayo i-angina ayiqondwa ngokugcwele, kodwa kucatshangwa ukuthi ihlanganisa lokhu okulandelayo: I-angina yokuzivocavoca: Ezigulini ezine-angina yokuzivocavoca, i-NORVASC yehlisa ukumelana okuphelele kwe-peripheral (afterload) ngesikhathi somsebenzi wenhliziyo kunoma yiliphi izinga lokuzivocavoca futhi inciphisa izinga. umkhiqizo wokucindezela, ngaleyo ndlela kunciphisa isidingo se-oxygen myocardial.
Ekuqaleni i-5mg kanye ngosuku, ikhuphuka ifike ku-10mg kanye ngosuku.
