Inombolo ye-Cas: 54-31-9 I-Molecular Formula:C12H11ClN2O5S
| I-Melting Point | 261-263°C |
| Ukuminyana | 1.16 (isilinganiso esinzima) |
| izinga lokushisa lokugcina | Umkhathi ongenayo, Izinga lokushisa Legumbi 2-8°C |
| ukuncibilika | I-DMSO: >5 mg/mL ku-60 °C |
| umsebenzi optical | N/A |
| Ukubukeka | Okuqinile Okumhlophe |
| Ubumsulwa | ≥98% |
I-Telmisartan yethulwa e-US ukwelapha umfutho wegazi ophakeme.Ingalungiswa ngezinyathelo eziyisishiyagalombili kuqala nge-methyl 4-amino-3-methyl benzoate;umjikelezo wokuqala nowesibili ube yindandatho ye-benzimidazole kwenzeka ezinyathelweni 4 no-6 ngokulandelana.I-Telmisartan ivimba isenzo se-angiotensin II (Ang II), i-molecule eyinhloko ye-renin-angiotensin-aldosterone system (RAAS).Kungokwesithupha kwalesi sigaba se-《sartans》 esizokhangiswa ngemva kwenhlanganisela eholayo i-Losartan.Umphumela wayo ohlala isikhathi eside (uhhafu wempilo wamahora angama-24) ungaba umehluko omkhulu nabanye abaphikisi be-angiotensin II.Ngokungafani namanye ama-ejenti amaningana akulesi sigaba, umsebenzi wawo awuncikile ekuguqukeni kwe-metabolite esebenzayo, i-1-O-acylglucuronide okuyi-metabolite eyinhloko etholakala kubantu.I-Telmisartan iyimbangi enamandla yokuncintisana yama-receptors e-AT1 alamula iningi lemiphumela ebalulekile ye-angiotensin II ngenkathi intula ukuhlobana kwe-AT2 subtypes noma amanye ama-receptors abandakanyeka kulawulo lwenhliziyo nemithambo yegazi.Ezifundweni ezimbalwa zomtholampilo, i-Telmisartan, ngethamo elilodwa ngosuku, yakhiqiza imiphumela esebenzayo futhi eqhubekayo yokwehlisa umfutho wegazi enezinga eliphansi lemiphumela emibi (ikakhulukazi ukukhwehlela okuhlobene nokwelashwa okuhlobene ne-ACE inhibitors ezigulini esezikhulile).
I-Telmisartan iyi-angiotensin II receptor antagonist.
