Inombolo ye-Cetilistat Cas: 282526-98-1 I-Molecular Formula:C25H39NO3

Incazelo emfushane:

Inombolo yeCas: 282526-98-1

Igama Lekhemikhali: Cetilistat

I-Molecular Formula:C25H39NO3

Synonimes:cetilistat Cetilistat(Alt-962) Cetilstat 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

imininingwane yemikhiqizo

I-Melting Point	72.0 kuya ku-76.0 °C
Ukuminyana	1.02
izinga lokushisa lokugcina	Ivalwe endaweni eyomile, engu-2-8°C
ukuncibilika	I-Chloroform (Kancane), i-Ethyl Acetate (Kancane)
umsebenzi optical	N/A
Ukubukeka	I-Cryst Emhlophe
Ubumsulwa	≥98%

i-pharmacodynamics

I-Cetilistat (eyaziwa nangokuthi i-ATL-962) yagunyazwa ngoSepthemba 2013 nguMnyango Wezempilo, Wezabasebenzi Nenhlalakahle YaseJapan ukuze kwelashwe ukukhuluphala, kukhawulelwe ezigulini ezinakho kokubili uhlobo 2 lwesifo sikashukela i-mellitus (T2DM) kanye ne-dyslipidemia, kanye nesisindo somzimba. inkomba (BMI)25 kg/m²naphezu kokwelashwa ngokudla kanye/noma ukuvivinya umzimba.Njenge-orlistat, i-cetilistat isebenza ngokuvinjwa kwe-pancreatic lipase emathunjini ukuze ivimbele ukumuncwa kwamafutha futhi ngaleyo ndlela inciphise ukumuncwa kwekhalori ekudleni.Uhlelo lwekhemikhali yezokwelapha aluzange luchazwe ezincwadini zesayensi, kodwa ilungelo lobunikazi elichaza i-cetilistat liphinde lichaze ukuhlanganiswa kwama-analogue anama-aryl substituent ahlukahlukene kanye nemisila ye-lipophilic.Ukuhlanganiswa kwe-cetilistat kuhilela ukufingqa kwe-hexadecylcarbonochloridate nge-2-amino-5-methylbenzoic acid;amanye ama-analogue ahlanganiswa ngokuhlukahluka kwe-carbonochloridate kanye nezingxenye ze-2-aminobenzoic acid.I-Cetilistat iyi-inhibitor enamandla ye-pancreatic lipase yomuntu negundane ene-IC_50sye-15 kanye ne-136 nM, ngokulandelana, ngokuvinjelwa okuncane kwe-trypsin noma i-chymotrypsin.