Inombolo ye-Cas: 147403-03-0 I-Molecular Formula: C24H29N5O3
| I-Melting Point | 230°C |
| Ukuminyana | 1.41g/cm³ |
| izinga lokushisa lokugcina | 2-8℃ |
| ukuncibilika | Cishe ayincibiliki emanzini, futhi ukuncibilika ku-ethanol ngu-5.5 mg/m |
| umsebenzi optical | +76.5 degrees (C=1, i-ethanol) |
| Ukubukeka | okuqinile okumhlophe noma okumhlophe, okunganuki |
iyi-non-peptide, esebenza ngomlomo i-angiotensin II (AT) receptor antagonist.Inokukhethwa okuphezulu okubhekiswe kuhlobo I-receptor (AT1) futhi ingaphikiswa ngokuncintisana ngaphandle kwanoma yimiphi imiphumela evuselelayo.Ingase futhi ivimbele ukukhululwa kwe-aldosterol ye-AT1 receptor mediated kumaseli e-adrenal glomerular, kodwa ayinawo umthelela ovimbelayo ekukhululweni okwenziwe nge-potassium, okubonisa umphumela wayo wokukhetha kuma-receptors e-AT1.Ukuhlolwa kwe-in vivo ngezinhlobo ezahlukene zezilwane ezinomfutho wegazi ophakeme kubonise ukuthi kunomphumela omuhle we-antihypertensive futhi akunawo umthelela obalulekile ekusebenzeni kwenkontileka yenhliziyo nokushaya kwenhliziyo.Awukho umphumela we-antihypertensive ezilwaneni ezinomfutho wegazi ojwayelekile
Izidakamizwa ze-antihypertensive.ingumphikisi we-angiotensin II (Ang II) ovimba ngokukhetha ukubophezela kwe-Ang II kuma-receptors e-AT1 (umphumela wawo othize wokuphikisa kuma-receptors e-AT1 ucishe ube mkhulu ngokuphindwe izikhathi ezingama-20000 kunowe-AT2), ngaleyo ndlela ivimbele ukufinyela kwemithambo nokukhululwa kwe-aldosterone, okuholela imiphumela ye-hypotensive
Umthamo wokuqala onconyiwe wamaphilisi ama-80mg (amaphilisi ama-2), aphuzwa ngomlomo kanye ngosuku.Ngokuvamile, uma kungasebenzi amaviki angu-4, umthamo ungakhuphuka ube ngu-160mg (amaphilisi ama-4) kanye ngosuku.Ngokwedatha yesicelo somtholampilo sangaphandle, umthamo omkhulu ungafinyelela ku-320mg (amaphilisi ayi-8) kanye ngosuku
1. Iziguli ezine-hypertension eyinkimbinkimbi nesifo sikashukela, umfutho wegazi ophakeme oyinkimbinkimbi ne-nephropathy noma isifo sikashukela esilula,
2.iziguli ezine-hypertension eyinkimbinkimbi ngokuhluleka kwenhliziyo noma i-myocardial infarction
