Inombolo ye-Rifampicin Cas: 13292-46-1 I-Molecular Formula: C43H58N4O12

Incazelo emfushane:

Inombolo ye-Cas:13292-46-1

Igama Lekhemikhali:I-Rifampicin

I-Molecular Formula:
I-C43H58N4O12

Synonimes:9,17,19,21-hexahydroxy-23-methoxy-2,4,12,1///;2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) i-furan-1,11(2-h) -dione,5,6;3-(((4-methyl-1-piperazinyl)imino)methyl)-rifamyci;3-((4-methyl-1-piperazinyl)iminomethyl )rifamycinsv;8-((4-methyl-1-piperazinyl)imino)methyl)rifamycinsv;8-(4-Methylpiperazinyliminomethyl)rifamycinSV;8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins; I-RIFAPIN "LEPETIT"

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukucaciswa Kwemikhiqizo

I-Melting Point	183 °
Ukuminyana	1.1782 (isilinganiso esinzima)
izinga lokushisa lokugcina	2-8°C
ukuncibilika	i-chloroform: i-soluble50mg/mL, icacile
umsebenzi optical	N/A
Ukubukeka	okubomvu okufiphele kuya kokubomvu okumnyama kakhulu
Ubumsulwa	≥99%

Incazelo

I-Rifampicin iyi-semisynthetic derivative ye-rifamicin B, i-macrolactam antibiotic kanye neyodwa yemithi elwa namagciwane engaphezu kwemihlanu evela engxubeni ye-rifamicins A, B, C, D, no-E, ebizwa ngokuthi i-rifamicin complex, ekhiqizwa yi-actinomycetes Streptomyces mediteranei ( Nocardia mediteranei).Yethulwa emsebenzini wezokwelapha ngo-1968. Ukwenziwa kwe-rifampicin kuqala ngesisombululo esinamanzi se-rifamicin, okuthi ngaphansi kwezimo zokusabela sifakwe i-oxid kuya kokuphuma kokusha kwe-rifamicin S (32.7.4), nokwakheka okumaphakathi kwe-rifamicin O (32.7. 3).Ukunciphisa ukwakheka kwequinone yalo mkhiqizo nge-hydrogen kusetshenziswa i-palladium ku-carbon catalyst kunikeza i-rifamicin SV (32.7.5).Umkhiqizo owumphumela uthola i-aminomethylation ngengxube ye-formaldehyde ne-pyrrolidine, enikeza i-3-pyrrolidinomethylrifamicin SV (32.7.6).Ukufaka i-oxidizing umkhiqizo owumphumela nge-tetracetate yomthofu ku-enamine kanye ne-hydrolysis elandelayo enesixazululo esimanzi se-ascorbic acid kunikeza i-3-formylrifamicin SV (32.7.7).Ukusabela lokhu nge-1-amino-4-methylpiperazine kunikeza i-rifampicin efunekayo (32.7.8).

ukusetshenziswa kanye nomthamo

I-Rifampin isetshenziswa njenge-antibiotic.Iphuma ku-semisynthetic ye-rifamycin B, i-macrocyclic antibiotic ekhiqizwa isikhunta i-Streptomyces mediterranei.I-Rifampin isetshenziselwa ukwelapha isifo sofuba, i-brucellosis, i-Staphlococcus aureus, nezinye izifo ezithathelwanayo.