Inombolo ye-Cas: 1115-70-4 I-Molecular Formula: C4H11N5
| I-Melting Point | 233-236 ℃ |
| Ukuminyana | 1.48 g/cm³ |
| izinga lokushisa lokugcina | 15-30 ℃ |
| ukuncibilika | Incibilika emanzini, incibilika ku-ethanol, futhi ayincibiliki ku-chloroform ne-benzene. |
| umsebenzi optical | +25.7 degrees (C=1, amanzi) |
| Ukubukeka | i-crystalline powder emhlophe |
I-molecular pharmacological mechanism of okwamanje ayiqondwa ngokugcwele.Kuyaziwa ukuthi isebenza okungenani esibindini, yehlise i-gluconeogenesis (okungukuthi ukukhiqizwa kweglucose) futhi yehlise ukumelana ne-insulin.Olunye ucwaningo lubonise ukuthi lungenza i-AMP isebenze i-protein kinase (AMPK), okungenye yezindlela ezibalulekile zokuvimbela i-gluconeogenesis yesibindi futhi ithuthukise ukuzwela kwe-insulin endleleni yokudlulisela isignali ye-insulin.I-AMPK, njenge-protein kinase, idlala indima ebalulekile hhayi kuphela endleleni yokubonisa i-insulin, kodwa futhi nasekulinganiseni okuphelele kwamandla kanye ne-glucose kanye ne-fat metabolism.Ukuhlolwa kwezilwane kanye nezifundo zomtholampilo kukhombisile ukuthi kungadala ushintsho olukhulu ekwakhekeni kwe-fecal microbiota kusifo sikashukela, okungahle kungagcini nje ukufaka isandla ekukhiqizweni nasekusebenzeni kwe-glucagon njenge-peptide-1 (GLP-1), kodwa futhi kufakazele ukuthuthukisa ukuzwela kwe-insulin. , okuphinde kube ngenye yezindlela ezibalulekile zomphumela wayo we-anti type 2 diabetes.
Lo mkhiqizo kufanele usetshenziswe ngemithamo emincane futhi kancane kancane anda ngokuvumelana nesimo sesiguli.Umthamo wokuqala walo mkhiqizo (amaphilisi e-hydrochloride) ngokuvamile u-0.5 amagremu, kabili ngosuku;Noma 0.85 amagremu, kanye ngosuku;Thatha kanye nokudla.
Lo mkhiqizo kufanele usetshenziswe ngemithamo emincane futhi kancane kancane anda ngokuvumelana nesimo sesiguli.Umthamo wokuqala walo mkhiqizo (amaphilisi e-hydrochloride) ngokuvamile u-0.5 amagremu, kabili ngosuku;Noma 0.85 amagremu, kanye ngosuku;Thatha kanye nokudla.
