Inombolo ye-Florfenicol Cas: 73231-34-2 I-Molecular Formula: C12H14Cl2FNO4S

Incazelo emfushane:

Inombolo yeCas: 73231-34-2

Igama Lekhemikhali: Florfenicol

I-Molecular Formula:C12H14Cl2FNO4S

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Omqondofana

2,2-dichloro-n-[(1r,2s)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
I-AQUAFEN FLORFENICOL NUFLOR
[r-(r*, r*)]-n-[1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide
[R-(R*,S*)]-2,2-DICHLORO-N-[1-(FLUOROMETHYL)-2-HYDROXY-2-[4-(METHYLSULFONYL)PHENYL]ETHYL]ACETAMIDE
I-SCH-25298
(r-(r*,s*))-methyleste
2,2-dichloro-n-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl
4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-benzenesulfonicaci
I-Flofeniol
I-FLUPROFEN
I-Fluorothiamphenicol
Sch-25298, Aquafen
I-Acetamide, 2,2-dichloro-N-(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-4-(methylsulfonyl)phenylethyl-
2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
I-Aquaflor
I-Aquafen, Nuflor, SCH-25298, [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl ]i-acetamide
2,2-Dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide
2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamid

Ukucaciswa Kwemikhiqizo

I-Melting Point	153 °
Ukuminyana	1.451±0.06 g/cm3(Okubikezelwe)1.1782(isilinganiso esinzima)
izinga lokushisa lokugcina	2-8°C
ukuncibilika	Incibilika ku-ethanol ukuya ku-25mM naku-DMSO ukuya ku-100mM
umsebenzi optical	N/A
Ukubukeka	Okumhlophe kuya kokumhlophe
Ubumsulwa	≥98%

Incazelo

I-Flofenicol iyimithi elwa namagciwane ene-fluorinated ebanzi futhi iphuma ku-thiamphenicol (Into No. 21357).Isebenza ngokumelene nokuhlukaniswa kwabantu emitholampilo yamagciwane e-enteric, okuhlanganisa i-E. coli, i-Klebsiella, i-Enterobacter, i-Citrobacter, i-P. mirabilis, ne-Salmonella (MIC₅₀s = 6.3-12.5 μg/ml).I-Flofenicol iphinde isebenze ngokumelene nokuhlukaniswa kwemitholampilo yamagciwane ahlukahlukene e-bovine kanye nengulube, kuhlanganise ne-P. multocida, A. pleuropneumoniae, kanye ne-B. bronchiseptica (MIC₅₀s = 0.25-4 μg/ml).Ivimbela umsebenzi we-peptidyl transferase kuma-ribosomes angu-70S ahlukanisiwe ku-E. coli uma isetshenziswa ekuhlanganiseni okungu-1 mM.Amafomu aqukethe i-florfenicol asetshenziswe ekwelapheni izifo ezithathelwanayo zokuphefumula ezinkomeni.

ukusetshenziswa kanye nomthamo

Iwuhlobo lwesidakamizwa esilwa namagciwane.Isetshenziswa njengemithi yezilwane elwa namagciwane ekwelapheni izifo ezibangelwa amagciwane ezingulube, izinkukhu nezinhlanzi.Isebenza kahle ekwelapheni isifo sezingulube, izinkukhu kanye nezinhlanzi ezibangelwa amagciwane azwelayo, ikakhulukazi ukwelapha izifo zokuphefumula kanye nezifo zamathumbu.