Inombolo ye-Cas: 330784-47-9 I-Molecular Formula: C23H26ClN7O3

Incazelo emfushane:

Inombolo yeCas: 330784-47-9

Igama Lekhemikhali:

I-Molecular Formula:C23H26ClN7O3

Omqondofana:(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine

4--[(3-Chloro-4-methoxybenzyl) amino]-2--[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxes

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukucaciswa Kwemikhiqizo

I-Melting Point	150-152°C
Ukuminyana	1.372
izinga lokushisa lokugcina	Ivalwe endaweni eyomile, Gcina efrijini, ngaphansi kuka -20°C
ukuncibilika	I-DMSO (Kancane), i-Methanol (Kancane, Eshisiwe)
umsebenzi optical	N/A
Ukubukeka	Okumhlophe kuya kokumhlophe
Ubumsulwa	≥98%

i-pharmacodynamics

(I-Zepeed) yagunyazwa uMnyango Wezempilo waseKorea ukwelashwa kwe-erectile dysfunction (ED) ngo-Agasti 2011.iyi-inhibitor yohlobo lwe-5 phosphodiesterase (PDE5) ekhethiwe kakhulu.kubikwa ukuthi iyi-PDE5 inhibitor ekhethwa kakhulu emakethe.Ukuqala kwe-Tmax kanye nengxenye yempilo nakho kuyahluka phakathi kwama-PDE5 inhibitors athengiswayo.I-Sildenafil ine-T_ubuningingehora elingu-1 nengxenye yempilo engu-3–5 h.I-Vardenafil icishe ifane ne-T_ubuningiye-0.6 h kanye nengxenye yempilo ye-4-6 h.I-Tadalafil ine-half-life ende kunazo zonke phakathi kwezidakamizwa ezithengiswayo nge-half-life ye-17 h.inokuqala okusheshayo kwesenzo esifinyelela ku-T_ubuningiku-0.6 h nengxenye yempilo engu-1.2 h.Ukuhlanganiswa kwe-(TA-1790) kuchazwe ezincwadini zelungelo lobunikazi.Umzila oyinhloko wokuqeda uphuma ngenyongo nendle.Kuphinde kwatholakala ukuthi iphinde yamuncwa kabusha nge-enterohepatic recirculation.