Inombolo ye-Cas: 171599-83-0 I-Molecular Formula: C 2 2 H 3 0 N 6 O 4 S·C 6 H 8 O 7 = 666.70
| I-Melting Point | 49-53° |
| Ukuminyana | 1.05 g/cm³ |
| izinga lokushisa lokugcina | indawo epholile, eyomile futhi ugweme ukuchayeka ekukhanyeni noma ekushiseni okuphezulu |
| ukuncibilika | Incibilika kalula ku-ethanol, i-acetone, i-ether, i-benzene ne-methylene chloride, kodwa ayincibiliki emanzini. |
| umsebenzi optical | [α]D20 = +61.0° (isixazululo se-ethanol) |
| Ukubukeka | i-crystalline powder emhlophe ukuya kokuphuzi |
Ngesikhathi sokuvuselela ucansi, i-parasympathetic nerve, i-non adrenergic ne-noncholinergic nerve (NANC) iziphetho namaseli e-vascular endothelial akhulula i-nitric oxide (NO) ngaphansi kwesenzo se-nitric oxide synthase (NOS).Emithanjeni yegazi, i-soluble guanylate cyclase (sGC) ivamise ukwenziwa isebenze ngokuthi NO, futhi i-sGC isebenza ku-guanosine triphosphate ukukhiqiza i-cGMP.I-cGMP ku-corpus cavernosum ye-penis yenza umphumela oqinile we-vasodilator ngokunciphisa ukugxila kwe-Ca2+ kumaseli abushelelezi emisipha ye-corpus cavernosum, okubangela ukuphumula kwamangqamuzana emisipha ebushelelezi kanye nokwanda kokugeleza kwegazi ngaphakathi kwe-corpus cavernosum, okuholela. ku-erection.I-Jinyang alkali yehlisa izinga lokuwohloka kwe-cGMP, ngaleyo ndlela igcine umphumela wokuphumula we-cGMP ku-corpus cavernosum yomthondo futhi ibangele ukuqhanyelwa kwepipi.Ku-vivo, i-cGMP yehliswa futhi yenziwa ingasebenzi yi-PDE5.
Ifanele ukwelapha i-erectile dysfunction (ED) yenduku, iyasebenza ekungasebenzi kahle kwe-erectile okubangelwa ukusetshenziswa kwama-antidepressants, ama-antipsychotics, nezidakamizwa ze-antihypertensive, kanye nokungasebenzi kahle kwe-erectile okubangelwa ukuhlinzwa noma ukuhlukumezeka.
Ingenziwa ibe amaphilisi, amaphilisi, amaphilisi aqinile, amaphilisi athambile, futhi ingasetshenziswa njengewayini lomuthi, uketshezi oluphuzwayo, ikhofi, ama-granules, amaphilisi ahlafunwayo, ama-lozenges, ishungamu, namanye amafomu omthamo.Kubantu abadala, umthamo kufanele ube ngu-10-100mg ngosuku, onganyuswa noma wehliswe ngokuvumelana nesimo somsebenzisi.Kungcono ukuyithatha esiswini esingenalutho (ikakhulukazi gwema ukuyidla ngokudla okunamafutha amaningi), futhi ungaphuzi utshwala ngaphambi kokusebenzisa Itiye (ukuphuza akufanele kudliwe ngesikhathi esifanayo, okungasho ukuthi ukuphuza utshwala ngesikhathi esifanayo. isikhathi singanciphisa kakhulu umsebenzi we-erectile we-Viagra).
Isikhathi esisebenzayo: Iningi labantu liyithatha ihora elilodwa ukuze iqale ukusebenza.Kunconywa ukuthatha imithi cishe ihora elingu-1 ngaphambi kokuya ocansini, nemiphumela yayo ehlala amahora angu-48 kuya kwangu-72, kanti eminye ingase ihlale amahora angu-116.
