Inombolo ye-Cas: 224785-91-5 I-Molecular Formula:C23H33ClN6O4S

Incazelo emfushane:

Inombolo yeCas: 224785-91-5

Igama Lekhemikhali:

I-Molecular Formula:I-C23H33ClN6O4S

Synonimes: HCL;Vardenafi;Nuviva;fafinafei;Valdenafil;Levitra, Valdenafil;USP/EP/BP;Levitra,Valdenafil.HCl;224785-91-5;

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukucaciswa Kwemikhiqizo

I-Melting Point	214-216°C
Ukuminyana	N/A
izinga lokushisa lokugcina	Umkhathi ongenayo, 2-8°C
ukuncibilika	N/A
umsebenzi optical	N/A
Ukubukeka	I-Cyrstalline emhlophe ukuya kokumhlophe
Ubumsulwa	≥98%

i-pharmacodynamics

kwakuyi-ejenti yesibili okufanele idayiswe futhi ibe nenzuzo yokuthi isikhathi sayo sokuqala asincishiswanga ngokuphuza umuthi isisu sigcwele .Inamandla izikhathi ezingu-30 njenge-inhibitor ye-PDE5 (isho i-IC50, i-3.9 nM) kune-sildenafil futhi inamandla izikhathi ezingu-10 kune-tadalafil, ngokukhetha okukhulu (>izikhathi ezingu-1,000) ku-PDE5 yomuntu kune-PDE2, i-PDE3, ne-PDE4 yabantu kanye ukukhetha okumaphakathi (>izikhathi ezingama-80) ze-PDE1.I-PDE inhibitory selectivity kanye namandla e-in vitro kanye ne-vivo ye-PDE5 inhibitor entsha.ivimbele ngokuqondile i-hydrolysis ye-cGMP nge-PDE5, nge-IC50 ye-0.7 nM (sildenafil 6.6 nM).I-IC50 ye-PDE1 yayingu-180 nM, ye-PDE6 11 nM, futhi ye-PDE2, PDE3 kanye ne-PDE4 ngaphezu kuka-1,000 nM.